To be fair... and to speak more about "looks" more than "worrying about their looks"... I/we make fun of Trump's looks all the time... orangeness, hair, weight, small hands, pursed lips, long tie, etc.... so by the same token, I wouldn't disqualify comments/cartoons that reference Nancy's looks as any more inappropriate.
I actually thought the botox cartoon was pretty funny, regardless if she has used botox or not... just that it juxtaposed the two notions of "blinking".