Vaccination - Primate Study

[Karl Frederick]

The first phase of a primate study " . . . was published three months ago in the
prestigious medical journal Neurotoxicology, and focused on the first two
weeks of life when the vaccinated monkeys received a single vaccine for
Hepatitis B, mimicking the U.S. vaccine schedule. The results, which you can
read for yourself here <https://fourteenstudies.org/pdf/primates_hep_b.pdf>,
were disturbing. Vaccinated monkeys, unlike their unvaccinated peers,
suffered the loss of many reflexes that are critical for survival."


Here's the whole article:
Andrew Wakefield, Scientific Censorship, and Fourteen Monkeys

[Zeno Swijtink]

The first phase of a primate study " . . . was published three months ago in the prestigious medical journal Neurotoxicology, and focused on the first two weeks of life when the vaccinated monkeys received a single vaccine for Hepatitis B, mimicking the U.S. vaccine schedule. The results, which you can

Thanks, Karl. This looks interesting.

I have a copy of the study from NeuroToxicology if someone is interested. Just let me know.

[Sylph]

The hep B vaccine in most of the world does not contain thimerisol.
This primate study was very small (difficult to make a case for a statistically significant effect) and is suspect, in my opinion, because Wakefield was involved.
Mercury in vaccines is not correlated with developmental problems in human children. One study on thimerisol and developmental disorders:
https://pediatrics.aappublications.org/cgi/content/abstract/118/1/e139
BACKGROUND. The prevalence of pervasive developmental disorders has increased in recent years. Links with the measles component of the measles-mumps-rubella vaccine and the cumulative exposure to thimerosal through other vaccines have been postulated.
OBJECTIVES. The purpose of this work was to estimate the pervasive developmental disorder prevalence in Montreal, Canada, in cohorts born from 1987 to 1998 and evaluate the relationship of trends in pervasive developmental disorder rates with: (1) changes in cumulative exposure to ethylmercury (thimerosal) occurring through modifications in the immunization schedule of young children and (2) trends in measles-mumps-rubella vaccination use rates and the introduction of a 2–measles-mumps-rubella dosing schedule during the study period.
CONCLUSIONS. The prevalence of pervasive developmental disorder in Montreal was high, increasing in recent birth cohorts as found in most countries. Factors accounting for the increase include a broadening of diagnostic concepts and criteria, increased awareness and, therefore, better identification of children with pervasive developmental disorders in communities and epidemiologic surveys, and improved access to services. The findings ruled out an association between pervasive developmental disorder and either high levels of ethylmercury exposure comparable with those experienced in the United States in the 1990s or 1- or 2-dose measles-mumps-rubella vaccinations

[Gene]

The first phase of a primate study " . . . was published three months ago in the
prestigious medical journal Neurotoxicology, and focused on the first two
weeks of life when the vaccinated monkeys received a single vaccine for
Hepatitis B, mimicking the U.S. vaccine schedule. The results, which you can
read for yourself here <https://fourteenstudies.org/pdf/primates_hep_b.pdf>,
were disturbing. Vaccinated monkeys, unlike their unvaccinated peers,
suffered the loss of many reflexes that are critical for survival."


Here's the whole article:
Andrew Wakefield, Scientific Censorship, and Fourteen Monkeys

This study has been completly discredited by the scientific community and has no value. The man has been proven to be a liar. check out what Wiki has to say about it. I believe that anyone of intelligence who checks the data will come to the same conclusion.

[Zeno Swijtink]

This study has been completly discredited by the scientific community and has no value. The man has been proven to be a liar. check out what Wiki has to say about it. I believe that anyone of intelligence who checks the data will come to the same conclusion.

Did you check the data??

Did you even have a look at this article whose main authors are from the Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine and was accepted for publication by the peer reviewed journal NeuroToxicology?

This is not the paper the Wikipedia entry on Wakefield talks about. The reference is: Hewitson L, et al. Delayed acquisition of neonatal reflexes in newborn primates receiving a thimerosal-containing Hepatitis B vaccine: Influence of gestational age and birth weight, Neurotoxicology (2009), doi:10.1016/ j.neuro.2009.09.008

More completely:

Delayed acquisition of neonatal reflexes in newborn primates receiving a thimerosal-containing Hepatitis B vaccine: Influence of gestational age and birth weight.

Laura Hewitson a,c,*, Lisa A. Houser a, Carol Stott c, Gene Sackett b, Jaime L. Tomko a, David Atwood d, Lisa Blue d, E. Railey White d, Andrew J. Wakefield c

a Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
b Washington National Primate Research Center, University of Washington, Seattle, WA 98195, United States
c Thoughtful House Center for Children, Austin, TX 78746, United States
d Department of Chemistry, University of Kentucky, Lexington, KY 40506, United States

I think this issue is interesting to follow and am agnostic about the durability of the results of this particular article. Just dismissing this for reason that a co-author was implicated in a retraction does not do. Just dismissing it because of some idea about small sample size without reading the analysis that shows that there is statistical significance for the difference, as Sylph does, will not do either.

As I wrote before I have a copy of the prepublication from NeuroToxicology if someone is interested. Just let me know.

[Sylph]

There is so much wrong with the "primate study"...

Why mix thimerisol with the hep B vaccine? Why not give the hep B without preservative as a control group? In the results the experimenters admit that the study doesn't tell us what is (allegedly) causing developmental delays, the hepB antigens or the thimerisol...
They added controls later. Four monkeys were added to beef up statistical significance?
The subjects were chosen "semi randomly". What does that mean? Semi randomly is like "semi pregnant"!
How does a day's delay in a rooting reflex relate to autism? There is no primate model for autism.
They originally measured 18 reflexes but threw out 5 to end up with 13 to increase apparent statistical power?
3 of 13 reflexes were delayed. One, to almost two days. Even if this is significant, perhaps this is because the poor little guys got a painful shot (full of antigens, as is per usual with a vaccine) as opposed to saline or no shot in the controls. It says nothing about the monkeys developing simian autism.

There is very significant COI with all the study participants. Several of the authors are involved in chelation therapy for "vaccine injury" and the lead author has an autistic or asberger's child in litigation. This crappy study will certainly be used in vaccine litigation.

They took the babies away from their mothers at birth and injected them and then killed them. What a waste! If we have to experiment on primates it should be a well-designed study that actually helps solve a real problem.

https://scienceblogs.com/insolence/2009/10/some_monkey_business_in_autism_research_1.php
Most developing countries use a tetravalent, pentavalent, or hexavalent vaccine containing multiple other antigens, such as diphtheria, tetanus, pertussis, IPV, Hib, and HepB antigens. The hepatitis B vaccine, if given at all, usually isn't given until at least six weeks of age as part of existing vaccine programs. So, when you come right down to it, this study isn't even looking at what it claims to be looking at or following the rationale that its authors claim. If it were, it would not be following the U.S. vaccination schedule. In reality, it looks very much as though this study is custom-designed to sow doubt and fear about the birth dose of hepatitis B vaccine in the United States. That, and it's almost certainly going to be used as ammunition for legal action and lawsuits. Just wait.

I do hope that the media will take a look at the first phase of the monkey study, at the second phase of the monkey study, at all phases of the monkey study. I hope that the media will actually look at how it was conducted, how Wakefield could possibly have gotten IACUC approval for such a badly designed, dubious study, and, most especially, who funded the study and how many undisclosed COIs there are in the study. And, while they're at it, I hope they don't forget to ask some inconvenient questions of Andrew Wakefield and Laura Hewitson about how the control group appears to have changed between abstract published two years ago and the paper published last fall, in which the control group mysteriously grew from three to seven monkeys without explanation. Come to think of it, why are they now referring to "fourteen monkeys"? There were originally 13 monkeys in the "vaccinated" group and three in the control group for a total of 16 monkeys. In the "first phase" report last fall, there were thirteen monkeys in the vaccinated group, three monkeys in the unvaccinated group, and four monkeys that appeared to have shown up out of nowhere to be included as a saline injection control group. That's twenty monkeys. In any case, how is it that there are now apparently fourteen vaccinated monkeys? One wonders if Wakefield added another monkey to the vaccinated group and did some more "monkeying" with the control groups, one does.
https://scienceblogs.com/insolence/2...ver_andrew.php

[Orm Embar]

Just a clarification, for those who have not had hospital births in recent years:

The first dose of Hep B vaccine is given within the first day of birth, often within the first 12 hours. Ask any mom who has had a hospital birth in the last 5-10 years.

Here is the recommendation from the CDC cut and pasted directly from https://www.cdc.gov/vaccines/recs/sc...chedule-pr.pdf
1. Hepatitis B vaccine (HepB). (Minimum age: birth)
At birth:
• Administer monovalent HepB to all newborns before hospital discharge.
• If mother is hepatitis B surface antigen (HBsAg)-positive, administer HepB and 0.5 mL of hepatitis B immune globulin (HBIG) within 12 hours of birth.
• If mother’s HBsAg status is unknown, administer HepB within 12 hours of birth. Determine mother’s HBsAg status as soon as possible and, if HBsAg-positive, administer HBIG (no later than age 1 week).

I'm not meaning to weigh in on the merits of the study, just clarifying the dosing schedule for the human vaccine.

-Larkin

snip:

[QUOTE=Sylph;106961]There is so much wrong with the "primate study"...

The hepatitis B vaccine, if given at all, usually isn't given until at least six weeks of age as part of existing vaccine programs. So, when you come right down to it, this study isn't even looking at what it claims to be looking at or following the rationale that its authors claim.

[Sylph]

Thanks, Larkin, for clarifying the hepatitis b vaccination schedule. The science blogger I quoted had it wrong. He's a surgeon, not a general practice Dr. My kids are too old to have gotten the newborn shots. They got the hep b vaccine as young teenagers.

[Sylph]

The widely publicized primate study is now withdrawn by the editors at NeuroToxicology:
Autism Blog - Wakefield Monkey Study Withdrawn by Editor Left Brain/Right Brain

[Karl Frederick]

Thanks for your follow-up. I appreciate knowing more of the story.

The widely publicized primate study is now withdrawn by the editors at NeuroToxicology:
Autism Blog - Wakefield Monkey Study Withdrawn by Editor Left Brain/Right Brain