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    Mayacaman's Avatar

    Why no one should believe COVID-19 is naturally-occurring

    Why no one should believe COVID-19 is naturally-occurring

    By: Lawrence Sellin
    July 4, 2020

    After six months of exhaustive investigation, the global scientific community has been unable to identify the natural source of COVID-19, that is, the when, where and how it "jumped" from animals to humans.

    Some now imply that we may never know the natural origin of COVID-19.

    In a news article recently published by the international science journal Nature, the progress, or lack thereof, identifying the natural source of COVID-19 was reviewed.

    According to the article, COVID-19 probably originated in bats, specifically horseshoe bats, which host two closely related coronaviruses, named RaTG13 and RmYN02, whose genomes are 96% and 93% identical to COVID-19, respectively.

    Both coronavirus samples were isolated from bats in Yunnan Province, RaTG13 in 2013 and RmYN02 in 2019, and were studied in the Wuhan Institute of Virology.

    Wuhan is where the outbreak of COVID-19 originated and about 1,000 miles from Yunnan.

    The Nature article does not mention that RaTG13 is actually a duplicate of another bat coronavirus, BtCoV/4991, about which there is nearly no published experimental data since it was isolated in 2013, despite clearly being a Potential Pandemic Pathogen.

    That is, except for the structure, analyzed only by Chinese scientists, practically nothing is known about RaTG13.

    The Nature article also does not mention that the receptor-binding domain of RmYN02 showed only a 61.3% sequence identity with COVID-19, meaning it is highly unlikely that RmYN02 could even bind to human cells.

    The Nature article suggests that pangolins (scaly anteaters), might be an intermediate host because some pangolin coronaviruses “share up to 92% of their genomes” with COVID-19, presumably bridging the gap between bats and humans.

    When asked about that possibility, Dr Ralph Baric, a coronavirus expert from the University of North Carolina, in a March 15, 2020 interview, stated unequivocally that pangolins were not the source of COVID-19:

    “Pangolins have over 3,000 nucleotide changes - no way they are the reservoir species [for COVID-19], absolutely no chance.”

    Nevertheless, the receptor-binding domain of COVID-19 is structurally closer to pangolins than bats indicating a recombinant event, in this case, likely artificial.

    In fact, Ralph Baric and Zheng-Li Shi, the “bat woman” from the Wuhan Institute of Virology, conducted just such an artificial receptor-binding domain insertion from a newly isolated bat coronavirus (SHC014) onto the “backbone” from SARS-CoV, the coronavirus responsible for the 2003 pandemic.

    In a December 9, 2019 interview, Dr Peter Daszak, President of the EcoHealth Alliance and a long-time collaborator with the Wuhan Institute of Virology, presumably referring to the Ralph Baric- Zheng-Li Shi experiments, stated “you can manipulate them in the lab pretty easily” inserting a spike protein “into a backbone of another virus.”

    Thus, an artificial recombinant event carried out in the laboratory would be a far better explanation of pangolin-like structures appearing on a bat coronavirus backbone than one occurring in nature, at least given the current state of knowledge.

    The most conspicuous sign of COVID-19 genetic manipulation is the presence of a furin polybasic cleavage site, a structure that is not present in any of the coronaviruses so far identified as possible direct ancestors.

    The authors of the RmYN02 article stretch credulity even further by claiming that RmYN02 has a precursor cleavage site.
    In reality, it is a weak attempt to offer a naturally-occurring explanation for the presence of the furin polybasic cleavage site in COVID-19.

    Unfortunately, the amino acid sequence PAA, the insertion cited by the authors, is chemically neutral, totally unlike COVID-19's polybasic PRRAR sequence and PAA has no ability to cleave anything.

    Based on the actual evidence, it is unlikely that RmYN02 is a natural close relative of COVID-19.

    Although COVID-19 appears to have been “pre-adapted” for human infection, the artificial insertion of the furin polybasic cleavage site may explain a potentially significant point mutation in COVID-19 that may have increased its infectivity.

    According to the article “The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity,”, over the course of the human pandemic, one amino acid position has changed from aspartic acid to glycine, increasing the stability of the spike protein and, thereby, making COVID-19 more infectious.

    As suggested by the authors, that mutation may have been what is known as a “positive selection” to compensate for the structural instability created after the artificial insertion of the furin polybasic cleavage site.

    The burden of proof is now on China to demonstrate that COVID-19 is naturally-occurring because most of the available evidence indicates otherwise.

    [ Source ]

    [Ed. (Evans) The "burden of proof" is also on the Anglo-Americans who worked on the "gain-of-function" research on developing the Chinese bat-cave viruses, funded by a 3.7 million dollar grant from Dr. Anthony Fausti of the NIH.

    Q. And who was one of the recipients of this 3.7 million dollar grant to do the 'gain-of-function' research at the BSL-4 Lab in Wuhan, China?

    A. None other than talking head, Dr. Peter Daszak, the arch-villain who has the ear of the well-meaning fairy god mother of the American "new left", Amy Goodman.]

    Last edited by Mayacaman; 07-08-2020 at 11:42 PM.
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    Re: Why no one should believe COVID-19 is naturally-occurring

    A naturally-occurring COVID-19
    is the real conspiracy theory

    By Lawrence Sellin
    Aug 20, 2020

    There are new indications that China manufactured the novel coronavirus.

    The unique structural features of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, produce an extremely high infection rate and multi-organ secondary infections making this virus more dangerous and challenging for therapeutic interventions.

    Although sharing the same human angiotensin converting enzyme-2 receptor, SARS-CoV-2 is more selective for the human receptor and is, overall, far more infectious than SARS-CoV-1, the coronavirus responsible for the 2002-2003 pandemic, which also originated in China.

    One of those unique features of SARS-CoV-2 is a furin polybasic cleavage site that facilitates membrane fusion between the virus and the human cell and is widely known for its ability to enhance pathogenicity and transmissibility, but is not present in any closely related bat coronaviruses.

    The enhanced ability for membrane fusion may be a cause for the multi-organ infection observed in SARS-CoV-2 patients.

    A new scientific study published on August 19, 2020 suggests that other structures in SARS-CoV-2, similar to those found in Middle East Respiratory Syndrome coronavirus (MERS-CoV), may also contribute to that alternate infection process.

    The MERS-CoV 2012 pandemic produced a total of 2519 cases and 866 deaths, an extraordinary 34% mortality rate.

    Like SARS-CoV-2, MERS-CoV is believed to have originated in bats of the beta-coronavirus lineage, but may have passed through camels as an intermediate host before infecting humans.

    Unlike SARS-CoV-2, which uses the angiotensin converting enzyme-2 receptor for human infection, MERS-CoV uses a different receptor, Dipeptidyl peptidase 4 (DPP4), and its overall structure is only 40% similar SARS-CoV-2, meaning one could not have evolved from the other.

    Yet, SARS-CoV-2 appears to possess a dual receptor strategy for the infection of human cells, similar to MERS-CoV.

    In a comparative sequence analysis of the N-terminal domain of the spike protein that drives the binding and fusion process, the authors identified three extended “loop” regions in SARS-CoV-2 and MERS-CoV, but not in SARS-CoV-1, which may give SARS-CoV-2 additional capability to bind to and enter a variety of human cells.

    Taken together the unique structural features of SARS-CoV-2 suggest a coronavirus that was highly adapted for human infection.

    Over the course of the COVID-19 pandemic, numerous unsuccessful attempts have been made to provide conclusive evidence that SARS-CoV-2 is naturally occurring.

    A recent non-peer reviewed article “A Proposed Origin for SARS-CoV-2 and the COVID-19 Pandemic,” written by Jonathan Latham and Allison Wilson and published on their own website has garnered some interest in the non-scientific media as a possible explanation for the natural origin of SARS-CoV-2.

    This elegantly-written and well-documented review, which provides a unique and valuable translation of a Chinese clinical study, is nevertheless marred by offering an untenable theory of the origin of SARS-CoV-2 based on the serendipitous linking of a series of undocumented assumptions.

    Although not concisely stated, the Latham-Wilson theory seems to suggest that SARS-CoV-2 originated as respiratory infections in miners working in a cave in Mojiang, Yunnan Province China in 2012, who were infected by a coronavirus while working among bat feces, presumably by RaTG13, SARS-CoV-2's alleged closest relative.

    Over time, RaTG13 rapidly evolved inside at least one of the miners to create SARS-CoV-2. Biological samples from that miner eventually found their way to the Wuhan Institute of Virology, where unfrozen samples of the fully human-adapted SARS-CoV-2 infected a laboratory worker and began the COVID-19 pandemic.

    First of all, the extent of viral evolution in a single patient that would be required to go from RaTG13 to SARS-CoV-2, about 1,200 nucleotides, is unprecedented in the annals of scientific inquiry.

    Latham and Wilson attribute the adaptation to the viral load within a large lung surface area and, in particular, a lengthy infection lasting over four months.

    Yet, despite the presence of an active infection of a coronavirus highly adapted for human infection, there is no evidence of human-to-human transmission, even though the Chinese clinical study provides no indication of special quarantine efforts and a therapeutic regime resembling that for ordinary respiratory infections, including fungal infections.

    Although it seems likely that the miners experienced an initial viral respiratory infection and secondary, probably bacterial infections, tests for viral infections, including SARS-CoV-1, were negative during the course of hospitalisation.

    It was only afterwards, that the Chinese clinical study mentions a positive test for an unidentified virus, one possibility being henipa-like virus, which was also discovered in the same cave along with numerous types of bat coronaviruses.

    Strangely, the Wuhan Institute of Virology was experimenting with RaTG13 during 2017 and 2018, while SARS-CoV-2 was supposedly tucked away in a freezer, the Chinese scientists never making the connection between RaTG13 and the miners' infection.

    Finally, although not conclusive in itself, it seems that such a unique, direct bat-to-human natural coronavirus infection would have been big news in the virology community in 2012, yet it went practically unnoticed.

    If the Latham and Wilson theory proves anything, it demonstrates the lengths one must go in evidence-stretching to show that SARS-CoV-2 is naturally-occurring, when one begins by precluding the possibility that it was manufactured in a laboratory.

    Lawrence Sellin, PhD is a retired US Army Reserve colonel. He has previously worked at the US Army Medical Research Institute of Infectious Diseases and conducted basic and clinical research in the pharmaceutical industry. His email address is [email protected]

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  6. TopTop #4
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    Re: Why no one should believe COVID-19 is naturally-occurring

    Check out this article – well ahead of the wave ->
    Bill Gates Foundation, Rothschild Vanguard & Blackrock / China manufacture Wuhan Coronavirus outbreak by funding both the creation of the virus and the vaccine. Bill Gates is the New World Order’s equivalent of a chief science officer. As such, his top priority is depopulation. His stated method is vaccines.

    Bill is walking in his fathers' footsteps {fathers, Plural, Ed. ] who was also tasked with depopulation while head of Planned Parenthood (47). A proud legacy of eugenicists. [ Re: "Eugenics" Must See; text here. Ed. ]

    On January 9, 2020, the UN announced that the Wuhan Coronavirus had a lot of similarities to SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome).

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