https://www.youtube.com/watch?v=ahWS5RQBJwE&t=321s
Dr. John Campbell, July 28, 2020.
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We haven't had an update from Dr. Campbell yet today, so I thought it would be wise to repeat this one from 5 months ago about how to stay safe. It's really all the same stuff you've been hearing. It's simple. And, in the Fall, this might all help prevent the flu season, too! I think there's more evidence in favor of masks than what he says...but if his argument is enough to get you to use one, I'm all for it!
https://www.youtube.com/watch?v=IkdPFCStA38
Dr. Campbell's latest update. 07/30/20.
https://www.youtube.com/watch?v=C4otDdciULY&t=260s
Here is Dr. Campbell's latest COVID-19 Update. 07/31/20.
https://www.youtube.com/watch?v=B0nszQtbsfU
Here is a brief online Interview. 07/31/20
Cultural versus scientific explanation
https://www.youtube.com/watch?v=VcT2eYrIBnQ
Here is today's COVID-19 update from Dr. Campbell. 08/01/20.
https://www.youtube.com/watch?v=kBifblbZcu8
Two new COVID-19 updates by Dr. Campbell. Includes one about long-term heart complications of COVID-19.
08/02/20.
https://www.youtube.com/watch?v=9MoPER6NxPk
https://www.youtube.com/watch?v=qAO60IU8dxQ
Here is today's COVID-19 update from Dr. Campbell. 08/03/20.
https://www.youtube.com/watch?v=HJKgUc3NzUo
Two more updates from Dr. Campbell. News re: the U.S. and Australia and Europe.
https://www.youtube.com/watch?v=aPFsPDm4s-0
https://www.youtube.com/watch?v=23vJ0CME8BI
Here is a new update from Dr. Campbell. 08/05/20.
https://www.youtube.com/watch?v=2GgQHm5SESc
Two more updates from Dr. Campbell. One is dedicated to The Americas. The other is on Europe. 08/06/20.
https://www.youtube.com/watch?v=9OWxhh4go3c
https://www.youtube.com/watch?v=CxA3Dp4VeQI
Here is today's update on COVID-19 from Dr. Campbell. This one is about testing. 08/07/20.
https://www.youtube.com/watch?v=tJNiXBz2M1k
Here is Dr. Campbell's "Weekend Update" on COVID-19 for 08/08/20.
https://www.youtube.com/watch?v=ufKbFEFpITc
Here is Dr. Campbell's latest COVID-19 update. He is interviewed about the pandemic timeline worldwide. 08/09/20.
https://www.youtube.com/watch?v=Lp6eahu83Lc
Here are two new updates from Dr. Campbell. Vaccine information. 08/12/20.
https://www.youtube.com/watch?v=6UJ2PL5ERVo
https://www.youtube.com/watch?v=GvmNXf7BXUw
Here's a DW interview of Dr. Campbell. He talks some about the reported Russian vaccine. 08/13/20.
https://www.youtube.com/watch?v=FaO8TrDh1bQ
The San Francisco Chronicle reports that there are currently TWO COVID-19 vaccine trials going on in the Bay Area. They are looking for hundreds of volunteers. You have to live in San Francisco, Oakland, or Santa Clara County.
https://www.sfchronicle.com/bayarea/...m_medium=email
Here is Dr. Campbell's latest International COVID-19 update. Some info re: opening schools in the U.S. 08/13/20.
https://www.youtube.com/watch?v=PXctsOmYY8k
Two new COVID-19 updates from Dr. Campbell. One of them has to do with women. And another international update, particularly Africa. 08/14/20.
https://www.youtube.com/watch?v=1DiF7zYMbnQ
https://www.youtube.com/watch?v=bQcS-UWBq4Q
Here is a one hour International update on COVID-19 from Dr. Campbell. 08/15/20.
https://www.youtube.com/watch?v=mT-zWFnfhYI
Two new updates from Dr. Campbell. One about children. Another about immunity. 08/18/20.
https://www.youtube.com/watch?v=eSVLeEtjP-4
https://www.youtube.com/watch?v=D5Z6wdu1eI0
Here is Dr. Campbell's latest COVID-19 update. 08/19/20.
https://www.youtube.com/watch?v=vdUPYyiGu-E
Here is Dr. Campbell with a special report on COVID-19 in South Africa. 08/20/20.
https://www.youtube.com/watch?v=pAzJ-OP-itE
IMPORTANT update from Dr. Campbell with an article from The Journal of Pediatrics. Personally, I have been highly skeptical all this time about the idea that children do NOT get COVID-19 or spread it. It seems pretty obvious to me that they do, as is true with many, many other illnesses. Here is some new published data that seriously supports this fact.
https://www.youtube.com/watch?v=-xOO9t5HWYs
Two new COVID-19 updates from Dr. Campbell. The first is a global update, beginning with new CDC information (some encouraging news, despite the overall numbers). The second is his usual Sunday update, ending with his overall reflections about where we are right now.
https://www.youtube.com/watch?v=RnkYr8KSYR8
https://www.youtube.com/watch?v=bldTawjH3Yw&t=12s
The media today is reporting about a possible emergency use authorization for the use of convalescent plasma. Everything I've heard about this approach is extremely positive. The only problems I can see are that the cost is likely to be high, and the amount available will likely be limited.
Dr. Campbell's new COVID-19 update. Hopefully encouraging news. And a bit about convalescent plasma treatment.
https://www.youtube.com/watch?v=cT9nfh8ZrFQ
Still waiting on monoclonal antibodies.
Dr. Campbell interviews a patient still recovering from COVID-19 five months ago. 08/25/20.
https://www.youtube.com/watch?v=sIqwtCx5xvE
A new update from Dr. Campbell. Can you get re-infected with COVID-19 if you've had it before? 08/25/20.
https://www.youtube.com/watch?v=zJJ5gw2cVkA&t=4s
Three new updates from Dr. Campbell. Two are short TV reports. The third has to do with well people spreading COVID-19 infection. And physical changes that persist in the body even in people who have no symptoms. Yikes! 08/26/20.
https://www.youtube.com/watch?v=opXKziqh9xw
https://www.youtube.com/watch?v=UzsodD8v3ak
https://www.youtube.com/watch?v=bUfuF3Il4ik
The CDC's new testing guidelines seem like a bad idea to me. We will never get control of this thing unless we can do massive testing and detailed contact tracing.
Okay, folks. Get ready. Here is Dr. Campbell's update about hydroxychloroquine! 08/27/20.
A study from Belgium suggests LOW DOSE hydroxychloroquine IS EFFECTIVE with COVID-19.
Previous studies have been quite flawed...AND using way too high a dose.
Dr. Campbell discusses these things in this video.
https://www.youtube.com/watch?v=2uzXHnUViro
Dr. Campbell presents a COVID-19 update from Iraq. 08/28/20.
https://www.youtube.com/watch?v=J2pt7owNsBU
Dr. Campbell's latest COVID-19 update. More on hydroxychloroquine (still not certain, but he is leaning toward LOW DOSE treatment being effective). And more on COVID re-infections (several cases now reported in the literature).
https://www.youtube.com/watch?v=SBn4e69tGlg
The media is also reporting a re-infection case here in the United States.
https://www.cnn.com/world/live-news/...4ca461b4ae6257
Here is Dr. Campbell's Global Weekend Update re: COVID-19. 08/29/20.
https://www.youtube.com/watch?v=L0ygkjSKNXI
I will be starting a new thread on WACCO starting September 1st for the September 2020 updates.
Here is the last August COVID-19 update from Dr. Campbell.
https://www.youtube.com/watch?v=fGUFfhIkA9E
I will start a new thread tomorrow for the September updates.
Quote:
Okay, folks. Get ready. Here is Dr. Campbell's update about hydroxychloroquine! 08/27/20.
A study from Belgium suggests LOW DOSE hydroxychloroquine IS EFFECTIVE with COVID-19.
Previous studies have been quite flawed...AND using way too high a dose.
Dr. Campbell discusses these things in this video.
COVID19 breaking news, August 28, 2020: New Belgian large-cohort
study shows hydroxychloroquine significantly reduces mortality
by Nitay Arbel
Dr. John Campbell, a retired British nursing school instructor and textbook author whose videoblog on COVID19 I have been following diligently, highlights a new observational study from Belgium that caused him to change his mind about hydroxychloroquine: he was always skeptical but now believes it is effective.
Hydroxychloroquine, evidence of efficacy
The original paper “Low-dose Hydroxychloroquine Therapy and Mortality in Hospitalized Patients with COVID-19: A Nationwide Observational Study of 8075 Participants” by L. Catteau et al., can be read here as a postprint (i.e., an accepted manuscript in press following peer review): https://doi.org/10.1016
/j.ijantimicag.2020.106144
Allow me to highlight some quotes from the actual paper:
[…]Early during the amplification phase of the epidemic in Belgium, and pending results of clinical trials, off-label administration of a low-dose regimen of HCQ sulphate in monotherapy (400mg twice on day 1, followed by 200mg twice a day from day 2 to 5, i.e. a total dose of 2400 mg) was recommended as an acceptable immediate treatment option for hospitalized COVID- 19 patients [8]. This guidance, officially released on March, 13th, was based on the following considerations: (1) HCQ was the only drug with demonstrated in vitro effect against SARS-CoV-2 available in Belgium at that time; (2) HCQ exhibited a superior in vitro antiviral effect in comparison to CQ, likely explained by the higher intracellular drug accumulated concentrations [9]; (3) limited pharmacokinetic data suggested that the selected dosage should have sufficient antiviral activity [10]; (4) chronic administration of HCQ for rheumatological disorders has not been associated with major safety signals since decades of use; (5) restricting HCQ use to well-selected COVID-19 patients monitored at hospitals appeared as a reasonable risk/benefit compromise considering the well-known dose-dependent cardiotoxicity of the drug; (6) it was advised to Belgian hospitals to administer this off-label regimen whenever possible within clinical studies.[…]
Patients treated either with HCQ alone and supportive care (HCQ group) were compared to patients treated with supportive care only (no-HCQ group) using a competing risks proportional hazards regression with discharge alive as competing risk, adjusted for demographic and clinical features with robust standard errors. […] Results: Of 8075 patients with complete discharge data on 24th of May and diagnosed before the 1st of May, 4542 received HCQ in monotherapy and 3533 were in the no-HCQ group. Death was reported in 804/4542 (17.7%) and 957/3533 (27.1%), respectively. In the multivariable analysis, the mortality was lower in the HCQ group compared to the no-HCQ group (adjusted hazard ratio [HR] 0.684, 95% confidence interval [CI] 0.617–0.758). Compared to the no-HCQ group, mortality in the HCQ group was reduced both in patients diagnosed ≤ 5 days (n=3975) and > 5 days (n=3487) after symptom onset (adjusted HR 0.701, 95% CI 0.617–0.796 and adjusted HR 0.647, 95% CI 0.525–0.797, respectively).
The senior authors are affiliated with Ghent University, but the sample is nationwide, namely: all hospital admissions with COVID19 in Belgium until May 24 for which proper documentation on admission and discharge could be secured, and who had been given either HCQ or just “standard of care” (i.e., patients who got other experimental treatments were excluded, whether or not they also received HCQ).
So what do the authors speculate about the mechanism?
Antiviral efficacy of HCQ in humans has been poorly studied so far with adequate methods. Questions have also been raised whether safe HCQ dosages are sufficient to reach antiviral activity in target pulmonary cells [34]. Translating in vitro data into in vivo drug concentration in tissue appears particularly challenging for HCQ, as plasma concentrations do not appear to be a reliable surrogate [35]. Preprint studies in animal models (non-humans primates and Syrian hamsters) also suggest that HCQ has no antiviral efficacy [36,37]. Clinical efficacy might however be mediated through immunomodulatory mechanisms [7], preventing the progression toward severe disease with over-inflammatory responses by dampening the cytokine storm [38]. HCQ has indeed been shown to decrease the production of pro-inflammatory cytokines, both ex vivo and in lung explant model [5,39,40]. In the same line, use of low-dose dexamethasone (one of the RECOVERY arm) was recently reported to significantly decrease mortality in COVID-19 patients requiring oxygen [28]. Also, HCQ has been suggested to have some anticoagulant properties that may be beneficial in preventing thrombotic events in complement to low-molecular weight heparin [41].
The authors also note that concerns about cardiotoxicity refer to much higher dosage regimes (12,000 mg over 10 days). I know anecdotally from a friend who got such high doses as standard treatment for acute malaria that this was not a pleasant experience. The low dosage regime considered here is normally associated with the management of autoimmune diseases like lupus and rheumatoid arthritis; anecdotally, friends and acquaintances have been taking such for years without serious adverse events. As Paracelsus so memorably wrote in 1538, “All things are poison and nothing is without poison; only the dose causes something not to be a poison” (Alle Dinge sind Gift, und nichts ist ohne Gift, allein die Dosis macht dass ein Ding kein Gift ist.)
[ Source ]@ 8:00 in the video, Dr. Campbell asks a serious Question: essentially, 'Why did the previous studies administer such large dosages, when the "appropriate dose" in the British National Formualary has always been 200 mg ?'
Note:
Dr. Campbell expresses his surprise at this flaw in the previous studies, but doesn't seem to grasp the obvious answer.
To wit: All the previous studies on the efficacy of Hydroxychloroquine /& Zinc as an effective antidote for SARS-CoV-2 were designed to fail.
-For the simple reason that the Pharmaceutical-Industrial Complex would thereby not miss out on Billions of Dollars, Euros, Pounds, Rupees & Yen in Profits gleaned from vaccinating 7 Billion people...
Yes, this is wonderful news, and even I am convinced that hydroxychloroquine, rightly dosed (which means low-dose), may very well reduce mortality in COVID-19 patients.
This is a very well-designed study, but perhaps the real clincher is the patient sample size: more that 8000 patients! This is data we can trust and believe. Then again, it is only ONE such study, and it is still the ONLY such study designed this well and with that kind of sample size. My lifelong policy about *anything* is that I want to see *three* studies that demonstrate the same thing.
Nevertheless, this is a really good study, and I think it is likely the data will be reproduced by others.