Zeno Swijtink
05-03-2010, 07:33 PM
Artificial light at night disrupts cell division, research show (https://cancerupdatestoday.blogspot.com/2010/04/artificial-light-at-night-disrupts-cell.html)
Newswise ˜ Just one "pulse" of artificial light at night disrupts circadian cell division, reveals a new study carried out by Dr. Rachel Ben-Shlomo of the University of Haifa-Oranim Department of Environmental and Evolutionary Biology along with Prof. Charalambos P. Kyriacou of the University of Leicester. "Damage to cell division is characteristic of cancer, and it is therefore important to understand the causes of this damage," notes Dr. Ben-Shlomo. The study has been published in the journal Cancer Genetics and Cytogenetics.
The current research was carried out by placing lab mice into an environment where they were exposed to light for 12 hours and dark for 12 hours. During the dark hours, one group of mice was given artificial light for one hour. Changes in the expression of genes in the rodents' brain cells were then examined.
Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases.(Research)(Clinical report): An article from: Environmental Health Perspectives
Earlier studies that Dr. Ben-Shlomo carried out found that the cells' biological clock is affected, and in the present research she revealed that the mode of cell division is also harmed and that the transcription of a large number of genes is affected. She states that it is important to note that those genes showing changes in their expression included genes that are connected to the formation of cancer as well as genes that assist in the fight against cancer. "What is certain is that the natural division is affected," Dr. Ben-Shlomo clarifies.
Cancer Genet Cytogenet. 2010 Feb;197(1):65-70.
Light pulses administered during the circadian dark phase alter expression of cell cycle associated transcripts in mouse brain.
<https://www.ncbi.nlm.nih.gov/pubmed?term=%22Ben-Shlomo%20R%22%5BAuthor%5D>Ben-Shlomo R, <https://www.ncbi.nlm.nih.gov/pubmed?term=%22Kyriacou%20CP%22%5BAuthor%5D>Kyriacou CP.
Department of Biology, Faculty of Science and Science Education, University of Haifa-Oranim, Tivon, Israel.
Abstract
The circadian mode of cell division has been known for more than a century, but the association between circadian rhythms and mitosis is not yet clear. Synchronization of circadian oscillators with the outside world is achieved because light, or other external temporal cues, have acute effects on the levels of the clock's molecular components. Thus, an important question is whether environmental signals also affect transcription levels of cell machinery genes in a similar manner? In a microarray analysis, we have tested the influence of light pulses on the expression of transcripts in the mouse brain. Light pulses consistently affect transcription levels of genes that are essential and directly control the cell cycle mechanism, as well as levels of genes that are associated with the various cell cycle checkpoints. The changes in the levels and the direction of these changes could possibly lead to cell cycle arrest. We also found consistent changes in transcription levels of genes that are associated with tumorigenesis and are directly implicated with enhanced proliferation and metastasis. Copyright (c) 2010 Elsevier Inc. All rights reserved.
Newswise ˜ Just one "pulse" of artificial light at night disrupts circadian cell division, reveals a new study carried out by Dr. Rachel Ben-Shlomo of the University of Haifa-Oranim Department of Environmental and Evolutionary Biology along with Prof. Charalambos P. Kyriacou of the University of Leicester. "Damage to cell division is characteristic of cancer, and it is therefore important to understand the causes of this damage," notes Dr. Ben-Shlomo. The study has been published in the journal Cancer Genetics and Cytogenetics.
The current research was carried out by placing lab mice into an environment where they were exposed to light for 12 hours and dark for 12 hours. During the dark hours, one group of mice was given artificial light for one hour. Changes in the expression of genes in the rodents' brain cells were then examined.
Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases.(Research)(Clinical report): An article from: Environmental Health Perspectives
Earlier studies that Dr. Ben-Shlomo carried out found that the cells' biological clock is affected, and in the present research she revealed that the mode of cell division is also harmed and that the transcription of a large number of genes is affected. She states that it is important to note that those genes showing changes in their expression included genes that are connected to the formation of cancer as well as genes that assist in the fight against cancer. "What is certain is that the natural division is affected," Dr. Ben-Shlomo clarifies.
Cancer Genet Cytogenet. 2010 Feb;197(1):65-70.
Light pulses administered during the circadian dark phase alter expression of cell cycle associated transcripts in mouse brain.
<https://www.ncbi.nlm.nih.gov/pubmed?term=%22Ben-Shlomo%20R%22%5BAuthor%5D>Ben-Shlomo R, <https://www.ncbi.nlm.nih.gov/pubmed?term=%22Kyriacou%20CP%22%5BAuthor%5D>Kyriacou CP.
Department of Biology, Faculty of Science and Science Education, University of Haifa-Oranim, Tivon, Israel.
Abstract
The circadian mode of cell division has been known for more than a century, but the association between circadian rhythms and mitosis is not yet clear. Synchronization of circadian oscillators with the outside world is achieved because light, or other external temporal cues, have acute effects on the levels of the clock's molecular components. Thus, an important question is whether environmental signals also affect transcription levels of cell machinery genes in a similar manner? In a microarray analysis, we have tested the influence of light pulses on the expression of transcripts in the mouse brain. Light pulses consistently affect transcription levels of genes that are essential and directly control the cell cycle mechanism, as well as levels of genes that are associated with the various cell cycle checkpoints. The changes in the levels and the direction of these changes could possibly lead to cell cycle arrest. We also found consistent changes in transcription levels of genes that are associated with tumorigenesis and are directly implicated with enhanced proliferation and metastasis. Copyright (c) 2010 Elsevier Inc. All rights reserved.