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phooph
03-18-2009, 01:41 AM
Contact: Charlotte Webber
[email protected]
44-207-631-9980
BioMed Central (https://www.biomedcentral.com/)
Frankincense oil -- a wise man's remedy for bladder cancer (https://www.eurekalert.org/pub_releases/2009-03/bc-fo031609.php)

Originating from Africa, India, and the Middle East, frankincense oil has been found to have many medicinal benefits. Now, an enriched extract of the Somalian Frankincense herb Boswellia carteri has been shown to kill off bladder cancer cells. Research presented in the open access journal, BMC Complementary and Alternative Medicine, demonstrates that this herb has the potential for an alternative therapy for bladder cancer.
Bladder cancer is twice as common in males as it is in females. In the US, bladder cancer is the fourth most common type of cancer in men, whilst in the UK it is the seventh most common cause of death amongst males.
HK Lin and his team, from the University of Oklahoma Health Sciences Center and Oklahoma City VA Medical Center, set out to evaluate frankincense oil for its anti-tumour activity in bladder cancer cells. The authors investigated the effects of the oil in two different types of cells in culture: human bladder cancer cells and normal bladder cells. The team found that frankincense oil is able to discriminate between normal and cancerous bladder cells in culture, and specifically kill cancer cells.
Gene expression analyses were performed to determine how frankincense oil affects bladder cancer cell survival. The team found that the oil suppresses cancer cell growth by arresting cell cycle progression and induces bladder cancer cell death by activating multiple cell death pathways.
Dr Lin said, "Frankincense oil may represent an inexpensive alternative therapy for patients currently suffering from bladder cancer."

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Notes to Editors
1. Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity
Mark Barton Frank, Qing Yang, Jeanette Osban, Joseph T Azzarello, Marcia R Saban, Ricardo Saban, Richard A Ashley, Jan C Welter, Kar-Ming Fung and Hsueh-Kung Lin
BMC Complementary and Alternative Medicine (in press)
During embargo, article available here: https://www.biomedcentral.com/imedia/9378358372323491_article.pdf?random=433357
After the embargo, article available at journal website: BMC Complementary and Alternative Medicine (https://www.biomedcentral.com/bmccomplementalternmed/)
Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.
Article citation and URL available on request at [email protected] on the day of publication
2. BMC Complementary and Alternative Medicine is an open access journal publishing original peer-reviewed research articles in interventions and resources that complement or replace conventional therapies, with a specific emphasis on research that explores the biological mechanisms of action, as well as their efficacy, safety, costs, patterns of use and/or implementation. BMC Complementary and Alternative Medicine (ISSN 1472-6882) is indexed/tracked/covered by PubMed, MEDLINE, CAS, Scopus, EMBASE, Cinahl and Google Scholar.
3. BioMed Central (BioMed Central | The Open Access Publisher (https://www.biomedcentral.com/)) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.

Yubajeff
03-19-2009, 10:44 AM
Please do us a favor and don't waste bandwidth and brain
width by reporting meaningless in vitro studies. Nearly anything can be shown to have anti-cancer effects in vitro; change a few experimental parameters and you will show mutagenicity and carcinogenicity. That presumes the researchers have some integrity in the first place. I've been married to a basic researcher with a med school faculty position. They don't hesitate to fudge their data to get some positive results, which are then published. At least clinical trials are subject to some oversight.
I'd rather read a good single anecdotal case report than this type of meaningless in vitro crap. You are just encouraging a counterproductive method which has proven useless and even dangerously distracting from real progress, which has been pitifully absent since I graduated from medical school 34 years ago, or even since I first studied cancer in high school 42 years ago. IMHO, of course.

phooph
03-19-2009, 11:12 AM
Please do us a favor and don't waste bandwidth and brain
width by reporting meaningless in vitro studies. Nearly anything can be shown to have anti-cancer effects in vitro; change a few experimental parameters and you will show mutagenicity and carcinogenicity. That presumes the researchers have some integrity in the first place. I've been married to a basic researcher with a med school faculty position. They don't hesitate to fudge their data to get some positive results, which are then published. At least clinical trials are subject to some oversight.
I'd rather read a good single anecdotal case report than this type of meaningless in vitro crap. You are just encouraging a counterproductive method which has proven useless and even dangerously distracting from real progress, which has been pitifully absent since I graduated from medical school 34 years ago, or even since I first studied cancer in high school 42 years ago. IMHO, of course.

OK, have at it:

Acetyl-keto-beta-boswellic acid induces apoptosis ...[Cancer Res. 2008] - PubMed Result (https://www.ncbi.nlm.nih.gov/pubmed/18281494?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)

Inhibitory effect of acetyl-11-keto-beta-boswellic...[Biochem Pharmacol. 2008] - PubMed Result (https://www.ncbi.nlm.nih.gov/pubmed/18430409?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)

Boswellic acid blocks signal transducers and activ...[Mol Cancer Res. 2009] - PubMed Result (https://www.ncbi.nlm.nih.gov/pubmed/19147543?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)

Inhibitory effects of beta-boswellic acids on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, expression of pro-inflammatory cytokines, arachidonic acid metabolism, and tumor promotion in mouse skin -- Huang et al. 2005 (1): 176 -- AACR Me (https://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/176-c)

Brain Cancer - Boswellia serrata- Astrocytome - Gliome Tumors (https://www.cancersalves.com/botanical_approaches/individual_herbs/boswellia.html)

Clinical Trials Results - National Cancer Institute (https://www.cancer.gov/search/ResultsClinicalTrialsAdvanced.aspx?protocolsearchid=5943708)

Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells -- Xia et al. 4 (3): 381 -- Molecular Cancer Therapeutics (https://mct.aacrjournals.org/cgi/content/abstract/4/3/381)

British Journal of Cancer - Abstract of article: Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity (https://www.nature.com/bjc/journal/v80/n5/abs/6690419a.html)

Boswellia Serrata and Standard Treatment or Standard Treatment Alone in Treating Patients Who Have Undergone Surgery and Radiation Therapy for Newly Diagnosed or Recurrent High-Grade Glioma - Full Text View - ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT00243022?intr=%22Vitamin+B+12%22&rank=46)

Wiley InterScience :: Session Cookies (https://www3.interscience.wiley.com/journal/121573429/abstract?CRETRY=1&SRETRY=0)

Elsevier: Article Locator (https://linkinghub.elsevier.com/retrieve/pii/S0361090X02001708)

Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase -- Safayhi et al. 261 (3): 1143 -- Journal of Pharmacology And Experimental Therapeutics (https://jpet.aspetjournals.org/cgi/content/abstract/261/3/1143)

pnicholson
04-13-2009, 10:50 PM
OK, have at it:

Acetyl-keto-beta-boswellic acid induces apoptosis ...[Cancer Res. 2008] - PubMed Result (https://www.ncbi.nlm.nih.gov/pubmed/18281494?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)

Inhibitory effect of acetyl-11-keto-beta-boswellic...[Biochem Pharmacol. 2008] - PubMed Result (https://www.ncbi.nlm.nih.gov/pubmed/18430409?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)

Boswellic acid blocks signal transducers and activ...[Mol Cancer Res. 2009] - PubMed Result (https://www.ncbi.nlm.nih.gov/pubmed/19147543?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum)

Inhibitory effects of beta-boswellic acids on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation, expression of pro-inflammatory cytokines, arachidonic acid metabolism, and tumor promotion in mouse skin -- Huang et al. 2005 (1): 176 -- AACR Me (https://www.aacrmeetingabstracts.org/cgi/content/abstract/2005/1/176-c)

Brain Cancer - Boswellia serrata- Astrocytome - Gliome Tumors (https://www.cancersalves.com/botanical_approaches/individual_herbs/boswellia.html)

Clinical Trials Results - National Cancer Institute (https://www.cancer.gov/search/ResultsClinicalTrialsAdvanced.aspx?protocolsearchid=5943708)

Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells -- Xia et al. 4 (3): 381 -- Molecular Cancer Therapeutics (https://mct.aacrjournals.org/cgi/content/abstract/4/3/381)

British Journal of Cancer - Abstract of article: Boswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity (https://www.nature.com/bjc/journal/v80/n5/abs/6690419a.html)

Boswellia Serrata and Standard Treatment or Standard Treatment Alone in Treating Patients Who Have Undergone Surgery and Radiation Therapy for Newly Diagnosed or Recurrent High-Grade Glioma - Full Text View - ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT00243022?intr=%22Vitamin+B+12%22&rank=46)

Wiley InterScience :: Session Cookies (https://www3.interscience.wiley.com/journal/121573429/abstract?CRETRY=1&SRETRY=0)

Elsevier: Article Locator (https://linkinghub.elsevier.com/retrieve/pii/S0361090X02001708)

Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase -- Safayhi et al. 261 (3): 1143 -- Journal of Pharmacology And Experimental Therapeutics (https://jpet.aspetjournals.org/cgi/content/abstract/261/3/1143)


nice. i am treating my little dog myself and this is very helpful. thank you.