phooph
10-25-2008, 11:37 AM
Already widely used in the cosmetics industry there looks to be no way to patent this compound and thus protect market share of any company that would want to put it through the very expensive FDA approval process. It can be applied to the skin or inhaled. Imagine a cancer treatment that not only didn't threaten your health and make your hair fall out, but smelled good too.
Tuesday, October 21, 2008
Methyl Jasmonate is a Stand Alone Treatment for Cancer and Leukemia (file:///Volumes/Documents/Health/Cancer/methyl-jasmonate-is-stand-alone)
This essay is reposted from our subscription blog in the public interest.
There is increasing evidence that methyl jasmonate (https://en.wikipedia.org/wiki/Methyl_jasmonate), a plant stress hormone, may be the ultimate stand alone treatment for ALL cancers and leukemias. The original research on MJ as a treatment for cancer began in Israel, but now scientists in other countries, including the US and Japan, have begun their own research programs on the anti-cancer properties of this simple compound.
MJ is a simple compound that in crude form is used to prevent the infection of plants by bacteria. In pure form, it is used by cosmetics companies as a scent. Now we know that MJ is a viable treatment for cancer and different forms of leukemia. Eventually, the Israeli scientists who discovered the anti-cancer properties of MJ will receive the Nobel Prize.
The ultimate anti-cancer compound is toxic to cancer but not normal cells. Preferably there would be no side effects such as vomiting and hair loss. Also, it would be nice if this compound was relatively inexpensive and easy to administer. Naturally, this is all wishful thinking. No such compound exists.
Or does it?
We all know that damage to the outer mitochondrial membrane is a primary signal for programmed cell death. However, the initiation of apoptosis AKA programmed cell is a complicated process. It requires the activation of many genes and the inactivation of others. Genetic defects in key gene activity can block the initiation of apoptosis. For example, during periods of oxidative stress or DNA damage the universal tumor suppressor p53 is activated. This protein promotes programmed cell death, thereby inhibiting the development of cancers. Unfortunately, over 50% of all cancers harbor genetic defects in the p53 gene rendering it ineffective in promoting cancer cell death.
Methyl jasmonate selectively kills cancer cells by binding to their mitochondria membranes and inducing damage. This damage initiates apoptosis, BUT it bypasses the normal complicated biochemical steps involved classical programmed cell death. MJ induced cell death is direct. It does not depend on the activation of other genes or the p53 status of the cancer cell.
PubMed reference
https://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15753398&itool=pubmed_docsum
Tuesday, October 21, 2008
Methyl Jasmonate is a Stand Alone Treatment for Cancer and Leukemia (file:///Volumes/Documents/Health/Cancer/methyl-jasmonate-is-stand-alone)
This essay is reposted from our subscription blog in the public interest.
There is increasing evidence that methyl jasmonate (https://en.wikipedia.org/wiki/Methyl_jasmonate), a plant stress hormone, may be the ultimate stand alone treatment for ALL cancers and leukemias. The original research on MJ as a treatment for cancer began in Israel, but now scientists in other countries, including the US and Japan, have begun their own research programs on the anti-cancer properties of this simple compound.
MJ is a simple compound that in crude form is used to prevent the infection of plants by bacteria. In pure form, it is used by cosmetics companies as a scent. Now we know that MJ is a viable treatment for cancer and different forms of leukemia. Eventually, the Israeli scientists who discovered the anti-cancer properties of MJ will receive the Nobel Prize.
The ultimate anti-cancer compound is toxic to cancer but not normal cells. Preferably there would be no side effects such as vomiting and hair loss. Also, it would be nice if this compound was relatively inexpensive and easy to administer. Naturally, this is all wishful thinking. No such compound exists.
Or does it?
We all know that damage to the outer mitochondrial membrane is a primary signal for programmed cell death. However, the initiation of apoptosis AKA programmed cell is a complicated process. It requires the activation of many genes and the inactivation of others. Genetic defects in key gene activity can block the initiation of apoptosis. For example, during periods of oxidative stress or DNA damage the universal tumor suppressor p53 is activated. This protein promotes programmed cell death, thereby inhibiting the development of cancers. Unfortunately, over 50% of all cancers harbor genetic defects in the p53 gene rendering it ineffective in promoting cancer cell death.
Methyl jasmonate selectively kills cancer cells by binding to their mitochondria membranes and inducing damage. This damage initiates apoptosis, BUT it bypasses the normal complicated biochemical steps involved classical programmed cell death. MJ induced cell death is direct. It does not depend on the activation of other genes or the p53 status of the cancer cell.
PubMed reference
https://www.ncbi.nlm.nih.gov/entrez/queryd.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15753398&itool=pubmed_docsum